A Comparative Study of Homocysteine, Cyanocobalamine, Folate, Lipid Profile and Serum Creatinine Level in Hypothyroid Subjects before and During Treatment
Abstract: Introduction: Hyperhomocystenemia is a disease involving abnormal homocysteine metabolism and is characterized by increased level of total homocysteine concentration (normal 5-15 ?mol/L). Many factors like dietary folate, cyanocobalamine deficiency or thyroid disorder are the most common causes for increased homocysteine level. This present study was planned to delineate the usefulness of levothyroxin, supplementation of folate and cyanocobalamine in patients of hypothyroidism to evaluate change in homocysteine level before and during treatment. Also to find out correlation between levothyroxin, cyanocobalamine and folate with homocysteine. Material and Method: The present study was conducted on 75 pateints of hypothyroidism of either sex in department of biochemistry, J.L.N. medical college and hospitals, Ajmer. Serum homocysteine, cyanocobalamine, folate level was measured by ELISA while thyroid function test were evaluated by RIA method. Result and discussion: There was highly significant change in homocysteine, cyanocobalamine, folate, total cholesterol, HDL, VLDL and LDL in hypothyroid subjects before and during treatment (P
Keywords: Homocysteine, cyanocobalamine, folate, levothyroxine, serum creatinine, lipid profile
How to Cite?: Kamlesh Tanwani, Deepa Thadani, Sarla Mahawar, "A Comparative Study of Homocysteine, Cyanocobalamine, Folate, Lipid Profile and Serum Creatinine Level in Hypothyroid Subjects before and During Treatment", Volume 11 Issue 4, April 2022, International Journal of Science and Research (IJSR), Pages: 535-538, https://www.ijsr.net/getabstract.php?paperid=MR22409122353, DOI: https://dx.doi.org/10.21275/MR22409122353