A Comparative Study of Homocysteine, Cyanocobalamine, Folate, Lipid Profile and Serum Creatinine Level in Hypothyroid Subjects before and During Treatment
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 3 | Views: 367 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Biochemistry | India | Volume 11 Issue 4, April 2022 | Popularity: 5.1 / 10


     

A Comparative Study of Homocysteine, Cyanocobalamine, Folate, Lipid Profile and Serum Creatinine Level in Hypothyroid Subjects before and During Treatment

Kamlesh Tanwani, Deepa Thadani, Sarla Mahawar


Abstract: Introduction: Hyperhomocystenemia is a disease involving abnormal homocysteine metabolism and is characterized by increased level of total homocysteine concentration (normal 5-15 ?mol/L). Many factors like dietary folate, cyanocobalamine deficiency or thyroid disorder are the most common causes for increased homocysteine level. This present study was planned to delineate the usefulness of levothyroxin, supplementation of folate and cyanocobalamine in patients of hypothyroidism to evaluate change in homocysteine level before and during treatment. Also to find out correlation between levothyroxin, cyanocobalamine and folate with homocysteine. Material and Method: The present study was conducted on 75 pateints of hypothyroidism of either sex in department of biochemistry, J.L.N. medical college and hospitals, Ajmer. Serum homocysteine, cyanocobalamine, folate level was measured by ELISA while thyroid function test were evaluated by RIA method. Result and discussion: There was highly significant change in homocysteine, cyanocobalamine, folate, total cholesterol, HDL, VLDL and LDL in hypothyroid subjects before and during treatment (P<0.0001). This emerging evidence suggest that these parameters are influenced by levothyroxine used in treatment of hypothyroid disorder and usefulness of supplementation of cyanocobalamine and folate for significant improvement of serum lipid profile. Conclusion: It is concluded that supplementation of levothyroxin, cyanocobalamine and folate in hypothyroid patients can cause significant decrease in level of homocysteine and significant improvement of serum lipid profile, which decreases risk of coronary heart disease in hypothyroid patients.


Keywords: Homocysteine, cyanocobalamine, folate, levothyroxine, serum creatinine, lipid profile


Edition: Volume 11 Issue 4, April 2022


Pages: 535 - 538


DOI: https://www.doi.org/10.21275/MR22409122353



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
Kamlesh Tanwani, Deepa Thadani, Sarla Mahawar, "A Comparative Study of Homocysteine, Cyanocobalamine, Folate, Lipid Profile and Serum Creatinine Level in Hypothyroid Subjects before and During Treatment", International Journal of Science and Research (IJSR), Volume 11 Issue 4, April 2022, pp. 535-538, https://www.ijsr.net/getabstract.php?paperid=MR22409122353, DOI: https://www.doi.org/10.21275/MR22409122353

Similar Articles

Downloads: 2 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies, Biochemistry, India, Volume 11 Issue 12, December 2022

Pages: 290 - 291

Homocysteinemia in a Case Presenting with Right Ventricular Dysfunction and Deep Vein Thrombosis

Dr. R. B. Grashia Packia Stary, Dr. P. Latha, Dr. R. Nagendran, Dr. E. Nithin Siromony

Share this Article

Downloads: 139 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Biochemistry, India, Volume 9 Issue 5, May 2020

Pages: 547 - 550

Study of Homocysteine Level in Myocardial Infarction in Rural Background of Jharkhand

Dr. Ruby Kumari, Dr. Kumar Pankaj Prabhat, Dr. Saurav Kumar

Share this Article
Top