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Original Research | Pathology | Volume 15 Issue 6, June 2026 | Pages: 651 - 663 | India
Role of Red Cell Distribution Width-Coefficient of Variation (RDW-CV) in Detection of Iron Deficiency Anaemia in Early Pregnancy: A Case-Control Study
Abstract: Background: Iron deficiency anaemia (IDA) is a major health concern among pregnant women, especially in developing countries. Early detection is crucial to prevent adverse maternal and fatal outcomes. Objective: To evaluate the diagnostic utility of Red Cell Distribution Width?Coefficient of Variation (RDW-CV) in detecting IDA during early pregnancy (≤20 weeks) and compare it with serum ferritin and serum iron. Methods: A hospital-based case-control study was conducted at Calcutta National Medical College and Hospital (July 2023?December 2024) among 100 anaemic (Hb <11 g/dL) and 100 non-anaemic (Hb ≥11 g/dL) pregnant women. RDW-CV, serum ferritin, and serum iron were analysed. Results: Low ferritin (<30 ng/dL) and low iron (<72 mcg/dL) were found in 90% and 77% of anaemic women, respectively. RDW-CV >14.5% was seen in 71% of cases vs. 14% of controls (p<0.001). RDW-CV showed 76.66% sensitivity, 80% specificity, and AUC=0.79 (p=0.04). Conclusion: RDW-CV is a simple, reliable, and cost-effective early screening tool for IDA in pregnancy.
Keywords: Iron Deficiency Anaemia, RDW-CV, Serum Ferratin
How to Cite?: Dr. Sukhendu Dhibar, Dr. Piyali Ghosh, Dr. Saumitra Biswas, "Role of Red Cell Distribution Width-Coefficient of Variation (RDW-CV) in Detection of Iron Deficiency Anaemia in Early Pregnancy: A Case-Control Study", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 651-663, https://www.ijsr.net/getabstract.php?paperid=SR26610224429, DOI: https://dx.dx.doi.org/10.21275/SR26610224429