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Case Report | Urology | Volume 15 Issue 6, June 2026 | Pages: 522 - 523 | India
Metastatic Renal Cell Carcinoma Presenting as Hemiparesis and Seizure
Abstract: This case report describes an uncommon presentation of metastatic clear cell renal cell carcinoma in a 52-year-old man who initially presented with focal seizures and left-sided weakness caused by a cerebral metastatic lesion. Imaging studies revealed bilateral renal masses, inferior vena cava tumour thrombus, pulmonary metastases, and a brain lesion with significant mass effect. Histopathological examination confirmed clear cell renal cell carcinoma, ISUP grade 2. The patient was managed through a multidisciplinary approach involving whole-brain radiotherapy, corticosteroid support, and targeted therapy with pazopanib. Clinical improvement was observed with recovery of motor function and reduction in the size of the renal masses on follow-up imaging. This case highlights the importance of thorough evaluation in patients presenting with neurological symptoms and demonstrates the potential benefit of combining radiotherapy and tyrosine kinase inhibitor therapy in selected patients with metastatic renal cell carcinoma involving the brain.
Keywords: Renal cell carcinoma, Brain metastasis, Hemiparesis, Radiation, Pazopanib
How to Cite?: Karthi A P, Dineshan K M, "Metastatic Renal Cell Carcinoma Presenting as Hemiparesis and Seizure", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 522-523, https://www.ijsr.net/getabstract.php?paperid=SR26609113856, DOI: https://dx.dx.doi.org/10.21275/SR26609113856