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Case Study | Oncology Science | Volume 15 Issue 6, June 2026 | Pages: 620 - 627 | Mexico
Advanced Gastric Adenocarcinoma with Bilateral Krukenberg Tumor and Cutaneous Metastasis in a Female Patient: A Case Report
Abstract: Background: Cutaneous metastases and Krukenberg tumors are uncommon but clinically significant manifestations of gastric adenocarcinoma, often associated with advanced disease and poor prognosis. Patient: We report the case of a 48-year-old woman with no prior oncological history, diagnosed with diffuse gastric adenocarcinoma with signet-ring cells. Clinical Presentation: The patient presented with increased abdominal girth, diffuse abdominal and pelvic pain, fatigue, and a palpable lower abdominal mass. Subsequently, she developed multiple cutaneous lesions on the scalp, neck, breasts, back, and abdomen, which progressively increased in size. Key Diagnostic Findings: Gastroscopy confirmed diffuse gastric adenocarcinoma. Imaging studies revealed bilateral ovarian masses consistent with Krukenberg tumors. Cutaneous biopsy confirmed metastases of gastric origin. Laboratory findings showed elevated carcinoembryonic antigen (CEA) levels. Treatment and Intervention: Cytoreductive surgery was performed for the ovarian masses, and palliative management was indicated for cutaneous metastases. Systemic chemotherapy was initiated according to advanced gastric adenocarcinoma protocols. Results and Evolution: The patient experienced disease progression, with increased size and number of cutaneous lesions, persistent abdominal symptoms, and marked fatigue, reflecting a poor short-term prognosis. Conclusions: This case highlights the importance of early recognition of cutaneous metastases and Krukenberg tumors in patients with diffuse gastric adenocarcinoma due to their association with advanced disease and unfavorable outcomes.
Keywords: Gastric adenocarcinoma, Krukenberg tumor, Cutaneous metastases, Signet-ring cell carcinoma, Advanced gastric cancer
How to Cite?: Marianela Ascencio Paredes, Diana Montano Orostico, Jose Sabino Montiel Castro, Ivan Melendez Garcia, "Advanced Gastric Adenocarcinoma with Bilateral Krukenberg Tumor and Cutaneous Metastasis in a Female Patient: A Case Report", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 620-627, https://www.ijsr.net/getabstract.php?paperid=SR26609013651, DOI: https://dx.dx.doi.org/10.21275/SR26609013651