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Research Paper | Radiology and Medical Imaging Sciences | Volume 15 Issue 6, June 2026 | Pages: 409 - 415 | India
Correlation of Computed Tomography and Histopathology / Cytology in Bronchogenic Carcinoma
Abstract: Background: Bronchogenic carcinoma, arising from the bronchial epithelium, stands as the leading cause of cancer-related deaths worldwide. Early detection and accurate staging are vital for treatment choices. Computed Tomography (CT) plays an important role in diagnosing and staging, while histopathology/cytology provides the definitive diagnosis. Objectives: To evaluate the role of Computed Tomography and histopathology/cytology in the diagnosis of bronchogenic carcinoma, and to assess characterization and differentiation of subtypes. Materials and Methods: This prospective observational study included 100 patients with clinically suspected bronchogenic carcinoma. Evaluation was performed using contrast-enhanced multi-detector CT, followed by tissue diagnosis via CT-guided biopsy, bronchoscopic biopsy, or FNAC. Findings were correlated with histopathological diagnosis. Results: The study showed a male predominance (82%), with maximum incidence in the seventh decade (60-69 years). Cough was the most frequent presenting symptom (28%). The majority of tumors were centrally located (58%) and presented at an advanced stage (Stage IV in 57.53% of NSCLC cases). Squamous cell carcinoma was the most common histopathological subtype (36%), closely followed by adenocarcinoma (34%). CT demonstrated strong diagnostic reliability with an overall accuracy of 82% when compared to histopathology. Conclusion: CT is the primary imaging modality for detecting tumor extent, local invasion, and metastasis in bronchogenic carcinoma. While it shows strong correlation with histopathological subtypes, tissue examination remains the gold standard for definitive diagnosis and treatment planning.
Keywords: Bronchogenic carcinoma, Computed tomography, Histopathology, Cytology, Subtype, Squamous cell carcinoma, Adenocarcinoma, TNM Staging
How to Cite?: Dr. Shefali Dipal Kamdar, Dr. Jagruti K. Sutaria, Dr. Anjana Patel, Dr. Parthkumar Nakrani, "Correlation of Computed Tomography and Histopathology / Cytology in Bronchogenic Carcinoma", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 409-415, https://www.ijsr.net/getabstract.php?paperid=SR26608145100, DOI: https://dx.dx.doi.org/10.21275/SR26608145100