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Research Paper | Gynaecology | Volume 15 Issue 6, June 2026 | Pages: 356 - 360 | India
A Study of Correlation of Tumor Markers with Histopathological Types of Ovarian Tumors in a Tertiary Care Hospital, Kangra at Tanda (Himachal)
Abstract: Background: Ovarian tumors show wide clinical and histopathological variation. Tumor markers are useful adjuncts in preoperative assessment, risk stratification, and planning of treatment, but final diagnosis depends on histopathological examination. Aim: To study the correlation of tumor markers with different histopathological types of ovarian tumors in women attending a tertiary care hospital. Materials and Methods: This prospective observational study included 82 women with clinically, radiologically, and histopathologically proven benign and malignant ovarian tumors. Detailed history, clinical examination, imaging, operative findings, histopathology, and serum tumor markers including CA-125, beta-hCG, CA 19-9, CEA, alpha-fetoprotein, LDH, and inhibin were recorded. Results: The mean age was 43.32 ± 15.73 years. Serous cystadenoma was the most common tumor type (23.75%), followed by mucinous cystadenoma (20.00%) and mature cystic teratoma (16.25%). Mean CA-125 was 74.45 ± 32.25. CA-125 was markedly raised in serous cystadenocarcinoma compared with serous cystadenoma, and malignant epithelial tumors had significantly higher CA-125 levels than benign epithelial tumors (123.5 ± 60.7 vs 39.8 ± 8.1; p<0.0001). Teratoma showed higher alpha-fetoprotein and LDH values. Conclusion: Tumor markers provide useful supportive information and show meaningful association with histopathological tumor type, especially CA-125 in epithelial malignancy. However, histopathology remains the gold standard for diagnosis and classification.
Keywords: Ovarian tumor, Tumor markers, CA-125, Histopathology, Tertiary care hospital
How to Cite?: Dr. Deepanjali Saini, Dr. Ashok Verma, Dr Kamal Singh, "A Study of Correlation of Tumor Markers with Histopathological Types of Ovarian Tumors in a Tertiary Care Hospital, Kangra at Tanda (Himachal)", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 356-360, https://www.ijsr.net/getabstract.php?paperid=SR26531222701, DOI: https://dx.dx.doi.org/10.21275/SR26531222701