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Case Report | Pathology | Volume 15 Issue 4, April 2026 | Pages: 1724 - 1726 | India
A Tale of Two Primaries: Synchronous Gallbladder Adenocarcinoma and Breast DCIS
Abstract: Multiple primary malignancies are uncommon, and synchronous dual primaries diagnosed in the same surgical setting are exceptionally rare. We report an unusual case of synchronous gallbladder invasive adenocarcinoma arising from intracholecystic papillary neoplasm (ICPN) and ductal carcinoma in situ (DCIS), comedo type, of the breast in a 75-year-old woman. The patient presented with acute abdominal pain and a right breast lump, and radiological evaluation revealed a polypoidal gallbladder mass along with a suspicious breast lesion. Cholecystectomy and breast wide local excision specimens were received simultaneously for frozen section. Histopathology confirmed invasive gallbladder adenocarcinoma arising from ICPN and high-grade DCIS without invasion. Distinct morphological and immune-histochemical profiles supported independent primary origins. This rare synchronous presentation underscores the importance of comprehensive clinical and pathological evaluation to ensure accurate diagnosis and appropriate multidisciplinary management.
Keywords: DCIS of breast, Dual malignancies, ICPN, Invasive adenocarcinoma of gallbladder, Multiple primaries
How to Cite?: Dr. Bhaumik D. Patel, Shantanu S. Parikh, Dr. Falguni J. Goswami, "A Tale of Two Primaries: Synchronous Gallbladder Adenocarcinoma and Breast DCIS", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 1724-1726, https://www.ijsr.net/getabstract.php?paperid=SR26427223707, DOI: https://dx.doi.org/10.21275/SR26427223707