The Role of Radiogenomics in Adult Precision Medicine: A Systematic Review

Dr Smita Kachewar, Dr Swapnali Borade, Rahim Pathan

Abstract: Background: Radiogenomics integrates quantitative imaging features with genomic and molecular data to non-invasively characterise disease biology. In adult medicine, this approach has emerged as a powerful tool to address tumour heterogeneity, guide personalised therapy, and improve prognostication across multiple disease domains. Objective: To systematically review the global evidence on the clinical role, applications, and limitations of radiogenomics in adult populations. Methods: A systematic review of peer-reviewed literature was conducted following PRISMA guidelines. Studies evaluating associations between radiological features and genomic, transcriptomic, or molecular alterations in adult patients were included. Results: Radiogenomics has demonstrated robust correlations with key molecular pathways, driver mutations, tumour microenvironment characteristics, and clinical outcomes-particularly in oncology. Evidence supports its utility in treatment response prediction, survival stratification, and non-invasive molecular profiling. Conclusion: Radiogenomics is a validated and rapidly evolving pillar of adult precision medicine, with growing clinical relevance beyond oncology. Standardisation, prospective validation, and equitable global implementation remain key challenges.

Keywords: radiogenomics, medical imaging biomarkers, precision medicine, tumour genetics, non-invasive diagnostics

How to Cite?: Dr Smita Kachewar, Dr Swapnali Borade, Rahim Pathan, "The Role of Radiogenomics in Adult Precision Medicine: A Systematic Review", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 936-938, https://www.ijsr.net/getabstract.php?paperid=SR26414154713, DOI: https://dx.doi.org/10.21275/SR26414154713

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