Nanoparticles for Diabetic Foot Ulcers: A New Frontier in Targeted Drug Delivery and Regenerative Therapy

Reshma K J, Silpa S S

Abstract: Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes mellitus, affecting nearly 25% of patients during their lifetime and frequently leading to infection, amputation, and increased mortality. Impaired wound healing in diabetes necessitates advanced therapeutic strategies. Nanotechnology-based drug delivery systems have emerged as promising tools to enhance wound healing and tissue regeneration in DFUs. Nanoparticles, alone or in combination with scaffold-based systems, enable targeted drug delivery, antimicrobial action, angiogenesis promotion, and controlled release of bioactive agents. These nano-enabled approaches offer significant advantages over conventional therapies and represent an emerging frontier in DFU management. Given the current medical advancements, the application of nanoparticles in diabetic foot ulcer treatment presents a highly effective and in-demand therapeutic strategy. These nano-delivery systems offer a targeted and efficient method to promote wound healing, ultimately improving patient outcomes.

Keywords: Diabetic foot ulcer, Nanoparticles, Wound healing, Nanotechnology, Scaffolds

How to Cite?: Reshma K J, Silpa S S, "Nanoparticles for Diabetic Foot Ulcers: A New Frontier in Targeted Drug Delivery and Regenerative Therapy", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 738-745, https://www.ijsr.net/getabstract.php?paperid=SR26309210955, DOI: https://dx.dx.doi.org/10.21275/SR26309210955

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