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Original Article | Histopathology | Volume 15 Issue 3, March 2026 | Pages: 734 - 737 | India
Intensity Grading of CD10 Expression in Urothelial Carcinoma of the Bladder: A Cross-Sectional Observational Study
Abstract: Urothelial carcinoma of the urinary bladder is one of the most common malignancies of the genitourinary tract and is characterized by a high rate of recurrence and progression. Conventional histopathological parameters such as tumor grade and stage remain the cornerstone of diagnosis and prognosis. However, additional molecular markers are increasingly being investigated to better understand tumor behavior and improve prognostic evaluation. CD10, also known as common acute lymphoblastic leukemia antigen (CALLA) or neutral endopeptidase, is a cell surface metalloproteinase involved in the degradation of bioactive peptides and has been implicated in tumor progression in several malignancies. This study aimed to evaluate the intensity grading of CD10 expression in urothelial carcinoma of the bladder and to correlate it with histopathological parameters including tumor grade, stage, and muscle invasion. A cross-sectional observational study was conducted on 50 cases of histologically confirmed urothelial carcinoma specimens received in the Department of Pathology at a tertiary care hospital. Formalin-fixed paraffin-embedded tissue sections were stained with hematoxylin and eosin for histopathological evaluation and immunohistochemistry was performed using CD10 antibody. The intensity of CD10 expression was graded from 0 to 3 based on staining intensity. The majority of patients were in the sixth and seventh decades of life with a male predominance. Most tumors were high-grade urothelial carcinomas. CD10 expression was observed in a significant proportion of cases and higher staining intensity was predominantly associated with high-grade tumors and advanced stage disease. A positive correlation was noted between CD10 intensity score and tumor stage as well as muscle invasion. The findings of this study suggest that CD10 expression intensity correlates with aggressive pathological features in urothelial carcinoma and may serve as a potential prognostic biomarker. Incorporating immunohistochemical markers such as CD10 along with conventional histopathological parameters may help in better risk stratification and management of patients with bladder cancer.
Keywords: Urothelial carcinoma, CD10, Immunohistochemistry, Bladder cancer, Tumor grade, Tumor stage
How to Cite?: Dr. Gnana Prasuna. M, Dr. Mamatha, Dr. Naval Kishore, "Intensity Grading of CD10 Expression in Urothelial Carcinoma of the Bladder: A Cross-Sectional Observational Study", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 734-737, https://www.ijsr.net/getabstract.php?paperid=SR26306223624, DOI: https://dx.dx.doi.org/10.21275/SR26306223624