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Case Studies | Physical Medicine and Rehabilitation | Volume 15 Issue 3, March 2026 | Pages: 351 - 352 | India
Hoffmann Syndrome: A Reversible Hypothyroid Myopathy in a Young Adult
Abstract: Hoffmann syndrome is a rare manifestation of hypothyroid myopathy characterized by muscle weakness, pseudohypertrophy, and elevated muscle enzymes. Although alarming in presentation, it is potentially reversible with early diagnosis and treatment. We report a case of a 22-year-old male who presented with bilateral calf hypertrophy, lower limb pain, and muscle weakness. Investigations revealed severe hypothyroidism with markedly elevated creatine phosphokinase levels. The patient showed complete clinical and biochemical recovery following thyroid hormone replacement and a structured rehabilitation program. This case highlights the importance of considering endocrine causes in patients presenting with unexplained muscle hypertrophy and emphasizes the role of rehabilitation in functional recovery.
Keywords: Hoffmann syndrome, hypothyroid myopathy, pseudohypertrophy, creatine phosphokinase, rehabilitation
How to Cite?: Shruti Pandey, L. Nilachandra Singh, A. K. Joy Singh, Monica Moirangthem, "Hoffmann Syndrome: A Reversible Hypothyroid Myopathy in a Young Adult", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 351-352, https://www.ijsr.net/getabstract.php?paperid=SR26303183748, DOI: https://dx.dx.doi.org/10.21275/SR26303183748