Advances in Rapid Point-of-Care Molecular Diagnostics and Biosensing for Infectious Diseases: A Review

S Sowmya Priya, Pusthela Arun Raj, Vishnu MG

Abstract: Rapid point-of-care molecular diagnostics are reshaping infectious disease management by enabling early detection and decentralized testing. This review explores recent advances in isothermal amplification, CRISPR-Cas systems, nanomaterial-based biosensors, and digital health tools including AI and IoMT. Techniques such as LAMP and RPA, when paired with CRISPR, offer high accuracy in minimal-resource settings. Nanomaterials like gold nanoparticles and carbon nanotubes enhance sensitivity and portability, while paper microfluidics and wearable biosensors expand accessibility. Although challenges persist such as validation, regulation, and equitable deployment- these technologies show promise for transforming global diagnostic capacity. The review emphasizes the need for integration with health systems to realize the potential of these tools under WHO?s ASSURED framework.

Keywords: Point-of-care diagnostics, CRISPR-Cas, Isothermal amplification, Nano biosensors, AI in healthcare

How to Cite?: S Sowmya Priya, Pusthela Arun Raj, Vishnu MG, "Advances in Rapid Point-of-Care Molecular Diagnostics and Biosensing for Infectious Diseases: A Review", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1649-1654, https://www.ijsr.net/getabstract.php?paperid=SR26128161618, DOI: https://dx.doi.org/10.21275/SR26128161618