Use of Oxiris Filter in Continuous Renal Replacement Therapy for Postoperative Septic Shock with Multiorgan Failure: A Case Report

Lordian Nunci, Olta Ajasllari, Krenar Lilaj, Prof. Dr. Ditila Doracaj

Abstract: Postoperative intra-abdominal sepsis with septic shock and multiorgan failure remains a major challenge in intensive care. Adsorptive continuous renal replacement therapy (CRRT) membranes, such as Oxiris, have been proposed as adjunctive therapy in septic shock. We report a case of a 28-year-old patient who developed severe intra-abdominal sepsis one week after hemicolectomy with colostomy for ileus. Computed tomography (CT) revealed the abdominal wall and intra-abdominal collections near the colostomy. A second operation with colostomy relocation and drainage of retroperitoneal and intra-abdominal abscesses was performed. Intra- and postoperatively, the patient deteriorated into septic shock, acute respiratory distress syndrome (ARDS), thrombocytopenia, and anuric acute kidney injury (AKI). Blood cultures grew Klebsiella pneumoniae and broad-spectrum antibiotics were administered (piperacillin?tazobactam, tigecycline, metronidazole). In the intensive care unit, the patient required mechanical ventilation with PEEP 12 cmH?O, norepinephrine, and CRRT. The ICU team initiated CRRT with an Oxiris filter in a heparin-free circuit at an effluent dose of 22 ml/kg/h. Within 24 hours, urine output increased to >2 ml/kg/h. Inflammatory markers, including procalcitonin (initially 98 ng/mL), decreased within 48 hours, and vasopressor requirements declined. CRRT was continued for 72 hours. Renal function normalized by postoperative day 4 and the patient was extubated on day 5. This case illustrates the potential benefit of Oxiris-based CRRT as part of a multimodal strategy in postoperative septic shock with multiorgan failure.

Keywords: septic shock, ARDS, acute kidney injury, continuous renal replacement therapy, Oxiris filter, postoperative sepsis, Klebsiella pneumoniae, intra-abdominal abscess

How to Cite?: Lordian Nunci, Olta Ajasllari, Krenar Lilaj, Prof. Dr. Ditila Doracaj, "Use of Oxiris Filter in Continuous Renal Replacement Therapy for Postoperative Septic Shock with Multiorgan Failure: A Case Report", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1139-1141, https://www.ijsr.net/getabstract.php?paperid=SR26105025821, DOI: https://dx.doi.org/10.21275/SR26105025821