Vasoactive Inotropic Score as a Predictor of Mortality in Neonatal Septic Shock: A Prospective Observational Study

Dr. Subhranshu Mihir Dash, Dr. Maulik Shah, Dr. Bhadresh Vyas, Dr. Shankar Lal Choudhary

Abstract: Background: Neonatal septic shock is associated with high mortality. The Vasoactive Inotropic Score (VIS) quantifies cardiovascular support and may serve as a prognostic marker. Objective: To evaluate VIS as a predictor of mortality in neonates with septic shock. Methods: A prospective observational study was conducted in the NICU of Shri M. P. Shah Government Medical College, Jamnagar, over 12 months. Neonates with septic shock receiving vasoactive drugs were enrolled. VIS was calculated at 0, 24, and 48 hours; VIS max was recorded. Primary outcome: in-hospital mortality. Results: 160 neonates were included. Mean gestational age was 35.2 weeks; 46% were term. Early-onset sepsis was seen in 75%. Culture positivity was 34%, predominantly Klebsiella pneumoniae. VIS max was significantly higher in non-survivors (60.2 vs 9.3; p<0.001). ROC analysis identified a VIS max >60 as the optimal mortality predictor (AUC 0.99). Conclusion: VIS is a simple, bedside tool strongly predictive of mortality in neonatal septic shock. A VIS max >60 identifies high-risk neonates warranting aggressive intervention.

Keywords: Neonatal sepsis, septic shock, vasoactive inotropic score, mortality, prognostic marker

How to Cite?: Dr. Subhranshu Mihir Dash, Dr. Maulik Shah, Dr. Bhadresh Vyas, Dr. Shankar Lal Choudhary, "Vasoactive Inotropic Score as a Predictor of Mortality in Neonatal Septic Shock: A Prospective Observational Study", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 194-196, https://www.ijsr.net/getabstract.php?paperid=SR25907000508, DOI: https://dx.doi.org/10.21275/SR25907000508