Unusual Presentation of Diffuse Large B-Cell Lymphoma: A Case of Abdominal Wall Involvement in an Elderly Patient

Cynthia Lorena Nava Palomo, Gerardo Davila Guzman, Valeria Leal Isla Flores, Yosira Guadalupe Lopez Alvarado

Abstract: Involvement of the abdominal wall by lymphoma is rare and often misdiagnosed because of its nonspecific clinical presentation. We report the case of an 80-year-old woman who presented with a rapidly enlarging subcutaneous abdominal mass, initially presumed to be a soft tissue abscess. Imaging was inconclusive, and a surgical biopsy was performed. Histopathological and immunohistochemical studies revealed Diffuse large B-cell lymphoma (DLBCL). Despite the diagnosis, the patient experienced a rapid clinical decline, precluding systemic therapy. Given the rarity of abdominal wall involvement in non-Hodgkin lymphoma and its potential for misdiagnosis, this case reinforces the need for heightened clinical suspicion and timely intervention in atypical soft tissue masses.

Keywords: Diffuse large B-cell lymphoma, extranodal lymphoma, abdominal wall mass, non-Hodgkin lymphoma, diagnostic delay

How to Cite?: Cynthia Lorena Nava Palomo, Gerardo Davila Guzman, Valeria Leal Isla Flores, Yosira Guadalupe Lopez Alvarado, "Unusual Presentation of Diffuse Large B-Cell Lymphoma: A Case of Abdominal Wall Involvement in an Elderly Patient", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 224-228, https://www.ijsr.net/getabstract.php?paperid=SR25905002838, DOI: https://dx.doi.org/10.21275/SR25905002838