Comparison of Carbetocin and Oxytocin in the Prevention of Post-Partum Hemorrhage Following Normal Vaginal and Cesarean Delivery

Dr. Priyanka Khan, Dr. Saroja C Kamatar

Abstract: Aim: To compare the efficacy of carbetocin and oxytocin for the prevention of postpartum hemorrhage (PPH) in women undergoing normal vaginal and cesarean delivery. Materials and Methods: This prospective comparative study was conducted in an urban tertiary care setting with 200 women, equally divided into normal vaginal delivery and cesarean delivery groups. Each group was further subdivided to receive either carbetocin 100 mcg IM/IV or oxytocin 10 IU IV infusion plus 10 IU IM post-delivery. Hemoglobin and hematocrit levels were measured pre-delivery and 24 hours post-delivery. The need for additional uterotonics was recorded. Results: Demographic variables such as age and parity showed no significant differences between the groups. Use of additional uterotonics was significantly lower in the carbetocin group for both delivery modes. No significant differences were noted in post-delivery hemoglobin and hematocrit levels between the two drugs. Conclusion: Carbetocin was associated with reduced need for additional uterotonics compared to oxytocin in both vaginal and cesarean deliveries, making it a suitable alternative for PPH prophylaxis.

Keywords: postpartum hemorrhage prevention, carbetocin, oxytocin, vaginal delivery, cesarean delivery

How to Cite?: Dr. Priyanka Khan, Dr. Saroja C Kamatar, "Comparison of Carbetocin and Oxytocin in the Prevention of Post-Partum Hemorrhage Following Normal Vaginal and Cesarean Delivery", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 728-729, https://www.ijsr.net/getabstract.php?paperid=SR25813153818, DOI: https://dx.doi.org/10.21275/SR25813153818