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Research Paper | Histopathology | Volume 14 Issue 8, August 2025 | Pages: 140 - 143 | Saudi Arabia
Cytological Alterations and E-Cadherin Expression in the Oral Mucosa of Shisha Smokers in Saudi Arabia
Abstract: Background: Shisha smoking is a prevalent form of tobacco use in Saudi Arabia and is a significant risk factor for oral cancer. Tobacco exposure alters cellular processes such as adhesion, proliferation, and differentiation. E-cadherin, a key cell adhesion molecule, plays a critical role in maintaining epithelial integrity, and its dysregulation may contribute to oral mucosal pathology. Objective: This study aims to assess cytological changes and the immunohistochemical expression of E-cadherin in the oral mucosa of Saudi shisha smokers. Methods: A cross-sectional study was conducted from March to June 2025, involving 200 buccal mucosa samples from Saudi participants of both genders. The study included 100 shisha smokers and 100 non-smokers as controls. Samples were collected using exfoliative cytology techniques. Immunohistochemical staining was performed to evaluate E-cadherin expression by assessing staining intensity and the percentage of positively stained cells. Data analysis was conducted using SPSS, with categorical variables expressed as frequencies and percentages. The chi-square test was used to assess associations, considering P
Keywords: Cytological changes, Oral mucosa, E-cadherin, Shisha smokers, Saudi Arabia
How to Cite?: Faris M Elmahdi, Maha Aouad, "Cytological Alterations and E-Cadherin Expression in the Oral Mucosa of Shisha Smokers in Saudi Arabia", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 140-143, https://www.ijsr.net/getabstract.php?paperid=SR25801113157, DOI: https://dx.doi.org/10.21275/SR25801113157