Unmasking the Inflammatory Face of Cerebral Amyloid Angiopathy: MRI Clues from a Rare Case

Dr. Adarsh B Hampole, Dr. Jeevika M U, Dr Abhishek Gowda

Abstract: Background: Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare but treatable subtype of cerebral amyloid angiopathy (CAA), characterized by a perivascular inflammatory response to amyloid-? deposition in cerebral vessels. Accurate diagnosis is crucial, as it responds well to immunosuppressive therapy. Case Presentation: We report a case of a 50-year-old female presenting with headache, fever and GTCS type seizure. MRI revealed areas of cortical and subcortical hyperintensities of parieto-temporal -occipital lobes and cortical and subcortical micro bleeds involving bilateral cerebral hemispheres with leptomeningeal enhancement on post contrast study. No evidence of systemic infection or neoplastic process was found. Based on clinical and radiologic criteria, a diagnosis of probable CAA-RI was made. Conclusion: CAA-RI should be considered in elderly patients with subacute neurological decline and distinctive MRI features. Early recognition can prevent invasive diagnostics and guide appropriate immunotherapy.

Keywords: CAA-RI, cerebral amyloid angiopathy, MRI, microbleeds, vasculitis, neuroinflammation

How to Cite?: Dr. Adarsh B Hampole, Dr. Jeevika M U, Dr Abhishek Gowda, "Unmasking the Inflammatory Face of Cerebral Amyloid Angiopathy: MRI Clues from a Rare Case", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1643-1645, https://www.ijsr.net/getabstract.php?paperid=SR25726215743, DOI: https://dx.doi.org/10.21275/SR25726215743