Spectrum and Outcomes of Postoperative Complications After Whipple Procedure: A Retrospective Analysis at a Tertiary Care Center

Dr. Anu Agarawaji, Dr. Suhas

Abstract: Background: The Whipple procedure (pancreaticoduodenectomy) is the standard surgical treatment for resectable periampullary malignancies. Despite improvements in technique and perioperative care, it carries substantial morbidity and mortality. Objective: To evaluate the profile and frequency of postoperative complications in patients undergoing Whipple procedure at ASRAM Hospital between January 2024 and June 2025. Methods: We retrospectively reviewed medical records of 18 patients and obtained follow-up information via telephonic interviews with patient attendants. Complications were classified according to International Study Groups definitions for pancreatic fistula and delayed gastric emptying. Results: Anastomotic leak occurred in 3 patients (16.7%), all progressing to peritonitis, sepsis, septic shock, and death. Three patients (16.7%) died of multi-organ dysfunction syndrome, and three (16.7%) died of intra-abdominal abscess. Among survivors, delayed gastric emptying was noted in 3 (16.7%), fistula formation in 4 (22.2%), and surgical site infection in 2 (11.1%). Overall mortality was 9/18 (50.0%). Conclusion: Infectious and anastomotic complications remain the leading causes of death following Whipple procedure. Early detection and standardized management protocols are essential to reduce morbidity and mortality.

Keywords: Whipple procedure, Pancreaticoduodenectomy, Postoperative complications, Anastomotic leak, Delayed gastric emptying

How to Cite?: Dr. Anu Agarawaji, Dr. Suhas, "Spectrum and Outcomes of Postoperative Complications After Whipple Procedure: A Retrospective Analysis at a Tertiary Care Center", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1558-1559, https://www.ijsr.net/getabstract.php?paperid=SR25725162946, DOI: https://dx.doi.org/10.21275/SR25725162946