Botryoid Neutrophils in Urosepsis: A Rare Morphological Observation on Peripheral Blood Smear

Dr. Firoz Sheikh, Dr. Chandni Krishnani, Dr Anil Kumar Verma

Abstract: This case report describes a 73-year-old female presenting with urosepsis and acute kidney dysfunction. Laboratory findings revealed elevated inflammatory markers and leukocytosis. Peripheral blood smear examination showed a rare morphological finding: botryoid neutrophils, characterized by marked nuclear hypersegmentation with a distinctive radial configuration. These neutrophils, observed in 70% of the total neutrophil population, displayed nuclei interconnected by thin interchromatin bridges. This unusual neutrophil morphology has been associated with various pathological conditions, including sepsis and uremia. The case highlights the importance of considering uremia in patients exhibiting neutrophilic hypersegmentation without macrocytosis, emphasizing the diagnostic value of peripheral blood smear examination in sepsis cases.

Keywords: Botryoid neutrophils, Urosepsis, Hypersegmented neutrophils, Peripheral blood smear, Sepsis

How to Cite?: Dr. Firoz Sheikh, Dr. Chandni Krishnani, Dr Anil Kumar Verma, "Botryoid Neutrophils in Urosepsis: A Rare Morphological Observation on Peripheral Blood Smear", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1403-1404, https://www.ijsr.net/getabstract.php?paperid=SR25722150852, DOI: https://dx.doi.org/10.21275/SR25722150852