Optic Neuropathy Induced by Linezolid in Drug-Resistant Tuberculosis: A Retrospective Study

Dr Neha Kathuria, Dr. Devendra Sharma, Dr. Navneet Bohra

Abstract: Linezolid has become a crucial drug in managing drug-resistant tuberculosis (DR-TB). However, reports of optic neuropathy associated with prolonged use raise significant clinical concerns. This retrospective study evaluates the incidence, clinical presentation, and outcomes of linezolid-induced optic neuropathy in a cohort of DR-TB patients. Among 86 patients treated with linezolid, 27.9% reported visual disturbances, and 5.8% were diagnosed with optic neuropathy. Early identification and intervention, including drug discontinuation, dose modification, and corticosteroid therapy, led to substantial recovery in most cases. The study underscores the importance of routine ophthalmologic monitoring in DR-TB treatment programs.

Keywords: Linezolid, Drug-Resistant Tuberculosis, Optic Neuropathy, Visual Monitoring, Treatment Safety

How to Cite?: Dr Neha Kathuria, Dr. Devendra Sharma, Dr. Navneet Bohra, "Optic Neuropathy Induced by Linezolid in Drug-Resistant Tuberculosis: A Retrospective Study", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1302-1303, https://www.ijsr.net/getabstract.php?paperid=SR25720203833, DOI: https://dx.doi.org/10.21275/SR25720203833