Sex-Specific Organ Dose and Cancer Risk Analysis in Thyroid Cancer Patients Treated with I-131: Insights from Dosimetry Modeling and Literature Comparison

Mosab Bashir, Ali S Ali, Alnazier O Hamza

Abstract: This study evaluates organ-specific radiation doses and associated cancer risks in thyroid cancer patients treated with 3700 MBq of I-131. Nineteen patients (16 females, 3 males) were retrospectively analyzed using OLINDA/EXM software for dosimetry calculations, with data obtained from post-therapy whole-body scans. The organs analyzed included the liver, kidneys, lungs, spleen, and urinary bladder wall. Results indicated that female patients received higher organ-specific doses and exhibited increased cancer risk probabilities, particularly for the lungs. The findings underscore the importance of integrating sex-specific risk assessment in to radionuclide therapy to enhance patient safety and support personalized treatment planning.

Keywords: I-131 therapy, organ dosimetry, cancer risk assessment, thyroid cancer, nuclear medicine

How to Cite?: Mosab Bashir, Ali S Ali, Alnazier O Hamza, "Sex-Specific Organ Dose and Cancer Risk Analysis in Thyroid Cancer Patients Treated with I-131: Insights from Dosimetry Modeling and Literature Comparison", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1852-1855, https://www.ijsr.net/getabstract.php?paperid=SR25720133154, DOI: https://dx.doi.org/10.21275/SR25720133154