Psoriasis as a Systemic Disease: Immune, Microbiota, and Mental Health Intersections

Naman Gupta

Abstract: Psoriasis is a chronic, immune-mediated skin disease characterized by erythematous, scaly plaques and systemic inflammation. Affecting approximately 2-4% of the global population, it significantly impairs quality of life and is associated with numerous comorbid conditions, including psoriatic arthritis, cardiovascular disease, and metabolic syndrome. This paper explores the multifactorial etiology of psoriasis, including genetic predisposition, immune dysregulation, and environmental triggers such as stress and microbiota imbalance. Emphasis is placed on the systemic implications of the disease, its psychological impact, and evolving treatment strategies. Current therapies range from topical agents and phototherapy to targeted immunomodulators. The integration of microbiome-based research and psychosocial support into treatment plans reflects a growing understanding of psoriasis as more than a dermatological disorder. Effective management requires a personalized, multidisciplinary approach that addresses both the physical and emotional burdens of the disease.

Keywords: psoriasis management, immune system disorder, genetic and environmental factors, microbiome research, psychosocial impact

How to Cite?: Naman Gupta, "Psoriasis as a Systemic Disease: Immune, Microbiota, and Mental Health Intersections", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 805-810, https://www.ijsr.net/getabstract.php?paperid=SR25605105616, DOI: https://dx.doi.org/10.21275/SR25605105616