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Research Paper | Pathology | India | Volume 14 Issue 3, March 2025 | Popularity: 5 / 10
Expression of Epidermal Growth Factor Receptor Protein: A Biological Marker for Oral Pre Cancer and Cancer
Dr. Adithiyan Udayasankar, Dr. Pramila Jain, Dr. Suryananth KB, Dr. Maneesh Sulya, Dr. Sonal Gupta
Abstract: Background: OSCCs aetiology is complex with numerous intrinsic and extrinsic causes, account for over 94% of oral malignancies in India. Survival, metastasis, and tumour growth have all been linked to high EGFR expression. Overexpression of EGFR, most likely as a result of increased intrinsic proliferative activity. Objective: Study the expression of EGFR in Premalignant and Malignant Oral Lesion. Methodology: Cross - sectional study conducted in dept. of pathology for 1.5 years using a questionnaire containing information related to risk factors of oral pre malignant and malignant condition after sectioning the tissues. Inclusion criteria: All tissues of oral biopsy which were histologically reported as proven case of Oral premalignant lesions and Oral Squamous Cell Carcinoma collected from 1st August 2022 to 31st January 2024 in the department of pathology, Gandhi Medical College, Bhopal. Exclusion criteria: Biopsies with tissue insufficient for histopathological evaluation, Recurrent cases, and patients taken neo - adjuvant therapy, Autolyzed samples. Result: 103 patients, mean age was 52.1?14.5years. Tobacco chewing reported by 92 (89.3%). The most common biopsy site was the buccal mucosa (58.3%). Chi - square test shows a statistically significant association between age category and lesion type (?? = 12.6, p = 0.028). Dysplasia (mild and moderate) exhibited 31.5% high EGFR expression, 31.5% low expression, and 37% with no expression. Conclusion: Increased EGFR expression correlates with the progression of oral lesions from premalignant to malignant stages.
Keywords: OSCC, EGFR, Oral cancer, Pre - malignant, Malignant
Edition: Volume 14 Issue 3, March 2025
Pages: 175 - 180
DOI: https://www.doi.org/10.21275/SR25305131610
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