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Review Papers | Neurology | Volume 15 Issue 6, June 2026 | Pages: 27 - 32 | India
Polytherapy in Drug-Resistant Epilepsy: Cellular and Molecular Mechanisms Underlying Cognitive Outcomes
Abstract: Epilepsy is a chronic neurological disorder characterized by recurrent seizures and is frequently associated with long-term cognitive impairment. While monotherapy remains the first-line treatment, approximately one-third of patients develop drug-resistant epilepsy and require polytherapy with multiple antiepileptic drugs. Although polytherapy can improve seizure control, combined pharmacological exposure may influence cognitive function through effects on neurotransmission, synaptic plasticity, neurotrophic signaling, metabolic regulation, and neural network stability. This review examines the cellular and molecular foundations of cognition, the mechanisms by which epileptic activity disrupts these processes, and how polytherapy may further modify cognitive outcomes. By integrating evidence on neural signaling, plasticity, and network-level changes, this review highlights the need to balance seizure suppression with preservation of cognitive function. Understanding these mechanisms is essential for guiding rational treatment strategies and improving quality of life in individuals with drug-resistant epilepsy.
Keywords: Epilepsy, Polytherapy, Antiepileptic drugs, Cognitive function, Synaptic plasticity, Neurotransmission, Neurotrophic signaling, Network connectivity
How to Cite?: Manasa Sankara Narayanan, "Polytherapy in Drug-Resistant Epilepsy: Cellular and Molecular Mechanisms Underlying Cognitive Outcomes", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 27-32, https://www.ijsr.net/getabstract.php?paperid=SR251220114404, DOI: https://dx.dx.doi.org/10.21275/SR251220114404