Impact of Sodium Fluoride (NaF) Toxicity in Acute and Chronic Conditions on the Teeth of Albino Rats (Rattus norvegicus)

Diksha N. Athawale, Milind D. Kale

Abstract: Dental caries remains one of the most prevalent chronic diseases observed in humans and experimental animals, as chemical agents are used in various formulations. Sodium fluoride (NaF) is one of the chemical agents which is widely used for its preventive effects against dental decay; however, excessive or prolonged exposure may cause dental fluorosis and enamel degeneration. Dental assessments were conducted to evaluate changes in tooth color and enamel integrity. Results showed that acute exposure led to yellowish discoloration, whereas chronic exposure caused degeneration of enamel and tooth edges. These findings indicate that sodium fluoride, while effective in preventing dental decay, can induce structural alterations in teeth if administered in high doses or for prolonged periods. The study underscores the importance of careful regulation of sodium fluoride intake and provides insights for optimizing its use.

Keywords: sodium fluoride, enamel degeneration, tooth decay

How to Cite?: Diksha N. Athawale, Milind D. Kale, "Impact of Sodium Fluoride (NaF) Toxicity in Acute and Chronic Conditions on the Teeth of Albino Rats (Rattus norvegicus)", Volume 14 Issue 11, November 2025, International Journal of Science and Research (IJSR), Pages: 139-141, https://www.ijsr.net/getabstract.php?paperid=SR251030234119, DOI: https://dx.doi.org/10.21275/SR251030234119