International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Research Paper | General Surgery | India | Volume 13 Issue 5, May 2024 | Rating: 5.7 / 10


Beyond Assumptions: Reimagining the Link between Cholelithiasis and Gallbladder Carcinoma- A Call for Personalized Clinical Strategies

Dr. P. Sneha Raj | Dr. R. Ashok Reddy [6] | Dr. Jitesh Vats | Dr. Ch. Sai Chaitanya


Abstract: Background: Gallbladder cancer, a relatively rare malignancy, presents a challenging landscape in the realm of surgical pathology. It is known to exhibit a predilection for the elderly population, typically manifesting in the seventh decade of life, in contrast to the more prevalent Cholelithiasis, which tends to affect individuals in their fourth decade. Objective: This cross - sectional observational study, conducted at Great Eastern Medical School & Hospital, Srikakulam, during the period from July 1st 2022 to March 31st 2024, aimed to investigate the frequency of gallbladder carcinoma in cases of acute and chronic cholecystitis, with a specific focus on the association with Cholelithiasis. Methods: A total of 310 Cholecystectomies were performed during the study period. Specimens obtained were macroscopically examined and subjected to histopathology. The reports were reviewed to determine the prevalence of gallbladder carcinoma in relation to acute and chronic cholecystitis, with an emphasis on cases involving Cholelithiasis. Results: Among the 310 cases, 27 (8.7%) presented with acute cholecystitis, and 280 (91.2%) exhibited chronic cholecystitis. Three specimens were excluded due to autolysis. Cholelithiasis was identified in 290 cases. Notably, only 2 out of the 290 cases with gallstones were found to have coexistent carcinoma of the gallbladder, as confirmed by histopathology. Conclusion: The study reveals a low frequency of gallbladder carcinoma associated with Cholelithiasis in the studied population. The incidental discovery of gallbladder carcinoma following cholecystectomy for Cholelithiasis is infrequent. These findings contribute valuable epidemiological insights, emphasizing the importance of considering individual patient profiles in the clinical management of gallbladder diseases. Further research and long - term follow - up studies may enhance our understanding of the complex interplay between Cholelithiasis and gallbladder carcinoma


Keywords: Cholelithiasis, carcinoma gallbladder, histopathology, and cholecystitis


Edition: Volume 13 Issue 5, May 2024,


Pages: 599 - 601



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