International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Research Paper | Neuroscience | India | Volume 12 Issue 8, August 2023

Examining Dopamine D5 Receptor Gene Polymorphism among Indian Population with Cervical Dystonia

B. Kumar [2] | H. P. Pandey | K. Tripathi [3] | R. K. Singh [3] | S. Mishra. T. T. Warner | M. R. Placzek

Abstract: Cervical dystonia or CD, also known as spasmodic torticollis, is a form of focal dystonia.It is caused by a multitude of environmental, neurochemical, and genetic factors but the exact etiology is still unknown. In the British and Italian population human dopamine D5 receptor has been considered as a susceptible gene for cervical dystonia. To view the hypothesis that DRD5 polymorphism is associated with the suceptible to cervical dystonia, We have examined differences in allele frequencies of DRD5 polymorphism in107 Indian patients with cervical dystonia and in 107 control subjects in India. Significant association was found for alleles 2, allele 6 and allele10 of the D5 receptor microsatellite. Allele 6 was found to be significant in patients than in control subjects. This results increased twofold risk for developing the disease. Allele 10 was found highly significant in control than in patients whereas allele 2 was also found significant in control than in patients. In conclusion, the finding of a significant association with an allele in the D5 receptor gene in patient with cervical dystonia may point out a pathogenic role of this gene.

Keywords: cervical dystonia, allelic association, dopamine D5 receptor

Edition: Volume 12 Issue 8, August 2023,

Pages: 981 - 983

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