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Research Paper | Biochemistry | India | Volume 12 Issue 7, July 2023
Level of Serum Copper in Patients with Dilated Cardiomyopathy (DCM)
Maharabam Purnima Devi | Laikangbam Shaini [2] | Thokchom Sachindeba Singh [2] | Okram Reshmi | Florida Ashem | Manojkumar Nagasundaram
Abstract: Background: Copper is an essential trace element that is required for human health. It is incorporated into a variety of proteins and metalloenzymes which perform essential metabolic functions. Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. It represents a leading cause of severe heart failure and heart transplantation in younger adults. Trace elements are being increasingly recognized as essential mediators of the development and progression of cardiomyopathy. Objectives: To evaluate serum copper levels in patients with DCM and in healthy controls, and to find any possible association between serum copper levels and DCM patients. Methodology: A cross - sectional study, consisting of 110 subjects out of which 55 subjects diagnosed with DCM and 55 healthy subjects, was carried out in the Department of Biochemistry in collaboration with Department of Cardiology, RIMS, Imphal, Manipur, India from October 2019 to September 2021. Serum copper levels were measured using Randox series RX Imola Autoanalyzer (manufactured 2007, UK). Results: Mean ? SD of copper (Cu) was found to be significantly higher in cases (131.827?44.683 ?g/dL) than the controls (94.455?30.861 ?g/dL) (p=0.009). Conclusion: Serum copper can be used in combination with other investigations such as ECG, chest X - ray, echocardiography for detecting DCM and could be utilized as an early biomarker for diagnosing DCM.
Keywords: Copper, Dilated Cardiomyopathy, Biomarker
Edition: Volume 12 Issue 7, July 2023,
Pages: 1491 - 1494