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Analysis Study Research Paper | Medical Surgical | India | Volume 12 Issue 6, June 2023
Clinicoepidemiological Study of Intracranial Extension of Rhino-Orbito-Cerebral Mucormycosis in a Tertiary Care Hospital
Abstract: Coronavirus disease 2019 (COVID-19) a deadly pandemic which first originated in Wuhan (SARS-CoV-2) spread across the entire globe. It was observed that there was a notable surge in fungal rhinosinusitis post second wave of covid. Injudicious use of steroids led to an extended immunocompromised state, thereby increasing susceptibility to fungal rhinosinusitis. The disease originates in the nasal/ sinus mucosae after inhalation of fungal spores and takes a rapidly progressive course extending to neighboring tissues, including the orbit, and sometimes to the CNS. Rhino-orbital-cerebral mycosis (ROCM) is a life-threatening fungal disease associated mostly with Mucoralean fungi. The infection presents as headache, vision loss, proptosis, ptosis, painful ophthalmoplegia, and peripheral face palsy, with a high morbidity (>80% for infections that spread to the CNS) and severe mortality, such as eyeball exenteration and vision loss. Early suspicion, rapid diagnosis, and initiation of treatment are the most important factors that determine prognosis in the management of mucormycosis. Imaging forms the cornerstone of management in patients with rhino-orbital-cerebral mucormycosis (ROCM). Impaired delivery of the antifungal drugs to the site of infection because of vascular thrombosis and limited aggressive surgery because of the complex anatomy of the rhino-orbital region cautions for early diagnosis and aggressive management in these patients. The main objective of this study is to evaluate patients with intracranial extension of ROCM and find a possible correlation of early intervention with outcome at our tertiary care center, Government medical college, Akola from February 2021 to August 2021.
Keywords: Rhino-Orbito-Cerebral Mucormycosis, Coronavirus, COVID-19
Edition: Volume 12 Issue 6, June 2023,
Pages: 2739 - 2742