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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 4, April 2023
Formulation and Evaluation of Novel Interpenetrating Polymer Network Microspheres for Controlled Release of Zaleplon
Abstract: Objective: A nonbenzodiazepine hypnotic medication called zaleplon is used to treat insomnia. Its low water solubility has a detrimental impact on its bioavailability. Zaleplon has been shown to have a 30% absolute bioavailability due to substantial pre - systemic metabolism during the first pass. It also has an extremely short half - life (about an hour), which favors the development of IPN based drug delivery system. Methods: Novel interpenetrating polymer network (IPN) of xanthan gum (XG) and poly vinyl alcohol (PVA) was prepared by emulsion cross - linking method to deliver model hypnotic drug, zaleplon, cross - linked with glutaraldehyde (GA) to form microspheres. Various formulations were prepared by changing the ratio of XG: PVA, extent of cross - linking in order to optimize the formulation variables on drug encapsulation efficiency and release rate. FTIR spectroscopy was done to confirm the formation of IPN matrix and the chemical stability of zaleplon after penetration of microspheres. Results: Microspheres formed were spherical with smooth surfaces as revealed by SEM. IPN formulation F9 composed of XG: PVA (1: 4) and glutaraldehyde (5.5 ml) gave the most advantageous entrapment (83.66?2.57%) and release results after 8 hrs (Q8h=54.00?0.61%) in PBS, pH 7.4 as compared to other compositions. These results suggest that the IPN microspheres are promising carriers for the controlled delivery of zaleplon.
Keywords: Zaleplon, Interpenetrating Polymer Network (IPN), Xanthan gum, Poly vinyl alcohol, Microspheres
Edition: Volume 12 Issue 4, April 2023,
Pages: 1086 - 1089