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Research Paper | Obstetrics and Gynecology | India | Volume 12 Issue 4, April 2023
Maternal and Fetal Outcome in Acute Fatty Liver of Pregnancy
Abstract: Background: Acute fatty liver of pregnancy is an idiopathic disorder with high mortality in the third trimester. The pathogenesis is unclear but there is emerging evidence of the genetic basis of AFLP where defective mitochondrial fatty acid beta oxidation in the fetus is implicated in some cases. Prompt delivery and intensive supportive care remain as the mainstay of treatment. Methods: We performed a descriptive prospective study of 22 patients with AFLP who met the Swansea criteria between March 2022 and March 2023. We analyzed the clinical features, laboratory results, maternal and neonatal outcomes. Results: Jaundice and Hypertension (59.1%) were the most common clinical manifestations. Nausea, vomiting and upper abdominal pain were the next common (40.9%) clinical symptoms. DIC was the major contributing factor for maternal mortality (60%) and maternal morbidity (45.5%). 50% pregnant women required ICU care and 22.7% maternal mortality was seen. Pregnant women with male fetuses (77.3%) was found to have a strong association with AFLP in our study. 54.5 % were preterm babies.50% babies required NICU care and 18.2% neonatal deaths was seen. Conclusion: Early diagnosis and termination of pregnancy plays a major role in preventing maternal mortality in AFLP.
Keywords: Acute Fatty Liver of Pregnancy, LCHAD enzyme, HELLP syndrome, DIC
Edition: Volume 12 Issue 4, April 2023,
Pages: 1199 - 1202