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Review Papers | Hematology | India | Volume 12 Issue 3, March 2023

Immature Platelet Fraction: A Promising Biomarker in Various Clinical Entities

Kavitha Thilak ^[3] | Abin Varghese ^[2] | Vineetha V ^[6]

Abstract: Reticulated platelets are immature platelets circulating in blood; they reflect the activity of megakaryopoiesis in the bone marrow. Therefore, they can be used as a non-invasive test in patients with thrombocytopenia in various clinical conditions. Reticulated or immature platelet assays are useful for the differential diagnosis of thrombocytopenia and for monitoring bone marrow recovery after chemotherapy or stem cell transplantation and several other clinical entities. The concentration of retPLT in bone marrow is on the average 2?3 times higher than in peripheral blood, where they correlate with megakaryocyte numbers. The platelets persist in the circulation for 7?10 days, retPLT have a much shorter lifespan (?

Keywords: Immature platelet Fraction, Thrombocytopenia, Covid, Dengue, sepsis, Coronary artery diseases, Liver diseases, preeclampsia

Edition: Volume 12 Issue 3, March 2023,

Pages: 1386 - 1393