Von Willebrand Factor Level among Sudanese Patients with Dengue Fever Disease
Abstract: Backgrounds and Aims Remarkable fluctuations in von willebrand factor (VWF) was observed in dengue infection. The knowledge of VWF in patients with dengue is not clear. Due to the increased recurrence of hemorrhage this study was undertaken. A cross-sectional study was conducted to investigate quantitative aspects of VWF Ag in dengue infected patients in Port Sudan Teaching Hospital, Red Sea State, Sudan. Materials and Methods 101 patients with dengue were enrolled in this study. Laboratory-positive dengue cases were confirmed by IgM enzyme-linked immunosorbent assay test and WHO criteria were used for classifying the dengue severity. Platelet count (PLT), Plasma Prothrombin time (PT), activated partial thromboplastin time (APTT), Fibrinogen (FB), and VWF Ag were performed. Results 81 patients (80.2 %) had classic dengue fever and 20 patients (19.8 %) had dengue hemorrhagic fever (DHF), classified as 5 patients (5.0 %) had DHF I, 13 patients (12.9 %) had DHF II and two of them developed dengue shock syndrome (DSS) and died (2.0 %).92.1 % had thrombocytopenia. PT, APTT, and FB were found to be statistically significant higher in patients when compared to the controls (P
Keywords: VWF, Dengue, Bleeding, Port Sudan, Sudan
How to Cite?: Bashir Abdrhman Bashir, "Von Willebrand Factor Level among Sudanese Patients with Dengue Fever Disease", Volume 6 Issue 2, February 2017, International Journal of Science and Research (IJSR), Pages: 1706-1710, https://www.ijsr.net/getabstract.php?paperid=ART2017573, DOI: https://dx.doi.org/10.21275/ART2017573