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Research Paper | Medicine | Indonesia | Volume 12 Issue 3, March 2023
Correlation between Lactate Dehydrogenase and Severity Clinical Degree of COVID-19 Patients
Halina Julia | Fajrinur Syarani [3] | Muntasir Abdullah | Putri Chairani Eyanoer [3] | Ranti Permatasari
Abstract: Background: Elevated serum lactate dehydrogenase (LDH)occurs in clinical conditions such as severe infection in COVID-19.1LDH is present in the lung tissue so that the occurrence of severe pneumonia causes the release of larger amounts of LDH which indicates the severity of COVID-19.2 This study aims to analyzed correlation between lactate dehydrogenase and severity clinical degree of COVID-19 patients who hospitalized at Adam Malik General Hospital, Medan, Indonesia. Materials and Methods: This study is an observational analytical study with a cross-sectional study design. We analyzed laboratory tests to identify tissue damage and inflammatory status in 180COVID-19 patients (50.6% males and 49.4% females) admitted to Department of Pulmonology and Respiratory Medicine, Adam Malik General Hospital. We investigated the relationship between LDH values(normal range < 353.5 U/L)3 and severity clinical degree (moderate, severe and critical) of COVID-19 patients. Statistical analysis was used chi-square test. Results: Patients had mean age moderate COVID-19 of 44 years, severe 55 years and critical 55 years. LDH levels were significantly correlated with gender (p=0.003); age (p = 0.032);and disease phase (p=0.000) of COVID-19 patients.LDH levels were not significantly correlated with comorbid COVID-19 patients (p=0,310).LDH levels were significantly correlated with the disease degree of COVID-19 patients (p = 0.000). Conclusion: There is correlation between lactate dehydrogenase and severity clinical degree of COVID-19 patients who hospitalized at Adam Malik General Hospital, Medan, Indonesia.
Keywords: COVID-19, LDH, disease degree
Edition: Volume 12 Issue 3, March 2023,
Pages: 1493 - 1501