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Research Paper | Anaesthesiology | India | Volume 12 Issue 2, February 2023

Intravenous Dexmedetomidine versus Intravenous Clonidine to Prolong Bupivacaine Neuraxial Anaesthesia

Dr. Kagitha Monika | Dr. K. Sindhu Smitha | Dr. K. Naga Praveena Pujitha

Abstract: Background: Regional (spinal or epidural) or general anesthesia are both alternatives for lower abdominal procedures. However, it has the disadvantages of a shorter block duration and less postoperative analgesia. In an effort to diminish the effects of local anesthetics even more while extending the duration of intraoperative and postoperative analgesia, adjuvants such vasoconstrictors, alpha-2 agonists, and opioids have all been used. Clonidine and Dexmedetomidine, ?-2 agonist agents are hypothesized to prolong the effect of spinal anaesthesia when given intravenously. Materials and Methods: This cross sectional study was conducted on 90 patients who were posted for surgical procedures below the umbilicus like abdominal & vaginal hysterectomies, diagnostic laparoscopies, inguinal hernias and lower limb orthopedic surgeries etc. The subjects were divided into 3 groups. Results: There was a significant statistical difference between the groups in terms of mean onset of sensory and motor blocks. (p: 0.01). The onset time was lowest in group A and highest in group C. There was a significant statistical difference between the groups in terms of mean duration of sensory and motor blocks. (p: 0.01). The duration time was highest in group A and lowest in group C. VAS score of group C subjects was highest and group A subjects was the lowest at all intervals. There was a significant statistical difference between the groups in terms of mean rescue analgesics administration time (p: 0.05). The time was highest in group A and lowest in group C. Conclusion: Intravenous dexmedetomidine significantly prolongs duration of sensory, motor blockade and analgesia as compared to clonidine.

Keywords: dexmedetomidine, clonidine, spinal anesthesia

Edition: Volume 12 Issue 2, February 2023,

Pages: 1325 - 1329