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Research Paper | Radiotherapy & Oncology | India | Volume 12 Issue 2, February 2023
Palliative Radiotherapy in the Management of Bone Metastasis: A Retrospective Analysis
Jain AK | Rajpurohit V S | Sharma R [2] | Jain K [3] | Tanwar S [2] | Meena R [5]
Abstract: Introduction: Bone is a frequent site of metastasis and typically indicates a short term prognosis in cancer patients. Prognosis of cancer becomes worse once the cancer metastasize to the bones. The treatment of bone metastasis is primarily palliative which requires multidisciplinary approach. Radiotherapy is the mainstay treatment in bone metastasis. The aim of this retrospective study is to analyze the effectiveness of radiotherapy in the symptoms of bone metastasis. Method: Total 168 patients diagnosed with bone metastasis were included in the study from Jan 2020 to May 2021 at the department of Radiation Oncology, SMS Medical College, Jaipur. Patients were treated with Co - 60 teletherapy in fractionation schedule ranging from 30 Gy in 10 daily fraction, 20 Gy in 5 daily fraction, 6.25 Gy per weekly fractionfor one month and 8 Gy in single fraction. Result: The median age of the cohort was 54.81 yrs. The most common site of primary tumor was the lung (30.35%) followed by breast (13.09%) and prostate (11.90%). The most common bone involved was spine (69.04%) followed by pelvis (10.71%).6.25Gy/ fraction schedule was most effective in the symptomatic relief in pain and 3 Gy/fraction schedule was most effective in stability/ movement. Conclusion: The current preferred institutional protocol of hypo - fractionated palliativeRTof6.25Gyperfractionweekly upto a maximum of four fractions given usually on Saturday showed better outcome to alleviate the symptoms of bone metastasis as compared with other palliative schedules of Radiotherapy.
Keywords: Bone metastasis, radiotherapy, fractionation schedule
Edition: Volume 12 Issue 2, February 2023,
Pages: 423 - 426