International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Neurology | India | Volume 12 Issue 12, December 2023


A Study of Clinical and Neuroradiological Profile of Inflammatory Optic Neuropathy in a Tertiary Care Center

Gurugubelli Yamuna Rani | N. V. Sundarachary


Abstract: Background: Optic neuritis is a common cause of acute onset of diminution of vision in patients presenting to the hospital. It is frequently associated with multifocal pathology such as multiple sclerosis in Western countries while more association is seen with neuromyelitisoptica (NMO) or myelitis in Asian countries. Aims and Objectives: To assess the clinical, neuro-radiological profile of patients with inflammatory optic neuropathy.To assess the short-term outcome of patients with inflammatory optic neuropathy. Materials and Methods: A prospective observational study done on 80 subjects diagnosed as inflammatory optic neuropathy. Other optic neuropathies, such as ischemic, infective, traumatic, toxic, hereditary, and compressive, were excluded from the study. All patients were treated as per treatment guidelines i.e., ONTT regimen which consisted of Injection of Methylprednisolone 1g for 3 days followed by oral prednisolone 1mg/kg body weight per day for 11 days and then tapered. Follow-ups were done at 3 months. Variables recorded include visual acuity testing, evaluation of pupils, fundus, color vision, visual field, and VEP. Results and conclusion: The majority of patients of optic neuritis are female with the majority belonging to middle age group (21-40 years) Diminution of vision is the most common complaint and in the majority of patients, and this is associated with periocularpain. Prolonged P100 latency is the most common abnormality seen on VEP which suggests demyelination in pathology. Demyelination in brain is seen on imaging of optic neuritis even in asymptomatic cases and MRI brain is needed in these patients for appropriate diagnosis and management. There was slightly increased frequency of retrobulbarneuritis which was different compared to other Indian studies.


Keywords: Optic neuritis, prospective study, ONTT, multiple sclerosis


Edition: Volume 12 Issue 12, December 2023,


Pages: 265 - 268


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