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Research Paper | Pathology | India | Volume 12 Issue 12, December 2023
Morphological Spectrum of Lymphocytes in Dengue Seropositive Patient: A Tertiary Hospital based Study
Abstract: Dengue is a vector borne disease transmitted by the bite of Aedes mosquito. The causative organism is a flavivirus, a single stranded RNA virus. It is also called Break bone disease because of the severe muscle spasm and pain associated with the disease. The severe manifestations of the disease is dengue haemorrhagic fever. Dengue infection is diagnosed usually by serological testing for NS1 Antigen, IgM and IgG . Haematological manifestations produced by dengue infection includes low platelet count and low WBC count. Severe dengue resulting to thrombocytopenia may lead to low haemoglobin level due to bleeding. In this study, the different morphology of the lymphocytes were analysed in dengue seropositive sample in relation to severity of thrombocytopenia and WBC count. Results: A total of 103 seropositive dengue samples were analysed, 55 were males and 48 were females with the median age of 42 years. The median platelet count was 1,08,735/cu.mm with the lowest platelet count of 11000/cu.mm. The lowest haemoglobin observed was 8.2 g/dl and the maximum Haemoglobin observed was 18.8 g/dl. Transformed lymphocytes were significantly increased in those samples with low platelet count and low WBC count. Conclusion: Transformed lymphocytes were significantly increased in those samples with low platelet count and low WBC count. Platelet count though are reduced in dengue seropositive patient but the presence of transformed lymphocytes were significantly associated with low platelet count and low WBC count.
Keywords: Dengue, seropositive, thrombocytopenia, transformed lymphocytes, low wbc
Edition: Volume 12 Issue 12, December 2023,
Pages: 941 - 944