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Research Paper | Anaesthesiology | India | Volume 11 Issue 11, November 2022

To Evaluate and Compare the Possible Analgesic Properties of Sevoflurane with Desflurane in Patients Undergoing Laparoscopic Cholecystectomies under Volatile Induction and Maintenance Anaesthesia (VIMA)

Dr. Gurleen Kaur | Dr. Mridul M Panditrao | Dr. Minnu M Panditrao | Dr. Nikhil Jaura

Abstract: Introduction: Sevoflurane, desflurane have been used in labour analgesia. Need more evidence to prove their analgesic properties, when used in VIMA. So, a randomized study single blinded comparative study was carried out. Method: 50 patients of either gender were randomly, equally allocated to 2 groups to be anaesthetized with sevoflurane or desflurane. Monitoring-routine multi parametric monitoring, depth of anaesthesia monitoring using Conox, qCON/qNOX kept between 40-60. Pain was scored using, VAS, before induction (T0), after extubation (T1), as shifted to Post Anaesthesia Care Unit (PACU) (T2), on demand of rescue analgesia/2 hours in PACU, whichever came first (T3). Rescue analgesia was administered before shifting to ward. Results: Demographically both the groups were similar. Haemodynamic parameters remained stable, suggesting, potentiation of fentanyl analgesia with appropriate depth of anaesthesia. VAS scores were consistently lower (1-3), at all time points. Recovery although far superior in desflurane group was also adequate even in sevoflurane group. In face of low VAS, rescue analgesia, had to be given pre-emptively before shifting to ward. Conclusion: Both IAAs have significant intraoperative and postoperative analgesic efficacy. Desflurane has rapid onset of analgesia, starting from time of induction. Amongst themselves the efficacy is similar.

Keywords: Volatile Induction Maintenance Anaesthesia (VIMA), Sevoflurane, Desflurane, Laparoscopic Cholecystectomy, VAS

Edition: Volume 11 Issue 11, November 2022,

Pages: 1168 - 1175