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Research Paper | Orthopaedic Surgery | India | Volume 11 Issue 11, November 2022

Intra Articular PRP Injection for Stage 1&2 Osteoarthritis of Knee

Dr Vaibhav Naidu Majji | Dr V Nageswara Rao | Dr Vijay Krishna Adusumalli

Abstract: Background: Platelet rich plasma (PRP) is defined as a volume of the plasma fraction of Autologous blood having a platelet concentration above baseline. Platelets contain bioactive proteins responsible for attracting macrophages, mesenchymal stem cells, and osteoblasts which not only promote removal of necrotic tissue, but also enhance tissue regeneration. Osteoarthritis of knee is a chronic and progressive joint disease that leads to articular cartilage damage, bone deformation, osteophyte formation and synovial inflammation. Treatment options for knee OA vary from simple analgesia in mild cases to knee replacement for advanced disease. Knee pain and early degeneration due to early stages of OA can be targeted with regenerative techniques such as use of intra articular platelet rich plasma was proposed. In this review, we present a comprehensive overview of the efficacy of Intra articular PRP for stage 1&2 OA of knee. Materials and Methods: A Prospective study was carried out in orthopaedics department from the month of January 2020 to December 2020, patients with Osteoarthritis of knee stage 1&2 have been included in this study and been followed up till December 2021 and have been evaluated based on WOMAC and VAS score system. Results: Among 31 patients who were willing and consented for study with Osteoarthritis of knee stage 1 (11 Males and 20 Females) the mean WOMAC score and VAS score were improved statistically following intra articular PRP injection. Conclusions: PRP plays an important role in tissue repair, regeneration, and the differentiation of mesenchymal stem cells to treat degenerative lesions of articular cartilage of the knee. This therapy appears to have minimal associated adverse events and have beneficial effects in terms of pain, stiffness, patient satisfaction and better functional outcomes.

Keywords: Intra Articular PRP, Platelet Rich Plasma OA Knee, Osteoarthritis Knee, PRP IN OA Knee, Stage 1 & 2 OA Knee

Edition: Volume 11 Issue 11, November 2022,

Pages: 35 - 39