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Research Paper | Biomedical Sciences | Volume 10 Issue 8, August 2021 | Pages: 905 - 908 | Indonesia
Lipid Profile and IL-1? Levels in Wistar Rats with Atherogenic Diet
Abstract: Background: Atherosclerosis is a pathological condition characterized by active, chronic, progressive inflammation and plaque in the artery walls. High cholesterol diet is one of the factors that can initiate inflammation and the production of proinflammatory cytokines such as IL-1? to cause atherosclerosis. This study aims to determine the value of lipid profile and IL-1? as a marker of atherosclerosis in male wistar rats fed atherogenic diet. As a positive control, a statin group atorvastatin 7.2 mg/kg, was used. Methods: The design of this research is a true post test control study laboratory experimental. Wistar male rats aged 10 weeks with body weight 150-200 grams were divided into 3 groups, normal, atherogenic (high cholesterol) and atorvastatin groups. Induction was carried out for 60 days and the administration of atorvastatin for 30 days. After 90 days of treatment, serum total cholesterol and IL-1? levels were measured. Results: There were significant differences in total cholesterol levels in the atherogenic group, normal group, and atorvastatin group (331.793 ?19.118 vs 113.864?6.615 vs. 144.132?35.214 mg/dL; P
Keywords: Lipid Profile, IL-1?, Atorvastatin
How to Cite?: Putu Yudha Ugrasena, Agung Wiwiek Indrayani, Ida Ayu Alit Widhiarthini, "Lipid Profile and IL-1? Levels in Wistar Rats with Atherogenic Diet", Volume 10 Issue 8, August 2021, International Journal of Science and Research (IJSR), Pages: 905-908, https://www.ijsr.net/getabstract.php?paperid=SR21816224350, DOI: https://dx.doi.org/10.21275/SR21816224350