Comparison between Oral Ethanol Vegetable Fern Leaves (Diplazium esculentum) Extract and Simvastatin to Improve Lipid Profile and Decrease F2-isoprostane Level in Wistar Male Rats (Rattus norvegicus) With Dyslipidemia

Marlene Irawan, Anak Agung Gde Budhiarta, Ida Sri Iswari

Abstract: Background: In dyslipidemia, lipid profile and lipid peroxidation increases. Lipid peroxidation was measured by F2-isoprostane level. Vegetable fern contains flavonoid and other constituent. This research aims to prove administration of oral ethanol vegetable fern leaves extract improves lipid profile and decrease F2-isoprostane level in male Wistar rats compared to simvastatin. Methods: This study used experimental pre test ? post test control group design, 14 wistar rats, males, 2, 5-3 months old, weighing 140-200 grams, divided into 2 groups. Simvastatin group was given simvastatin 0, 36 mg, whereas vegetable fern groupwas given oral ethanol vegetable fern leaves extract 100 mg, by intragastric force-feeding, once a day, for 21 days. Blood serum has been used to measure lipid profile and F2-isoprostane level. Results: There was a decrease in total cholesterol level after intervention, not only in simvastatin group (221.45 mg/dL vs 191.61 mg/dL; p=0.001) but also vegetable fern group (225.24 mg/dL vs 196.54 mg/dL; p=0.002). LDLalso decreased in both groups (135.67 mg/dL vs 86.69 mg/dL; p0.05). Conclusion: As conclusion, administration of oral ethanol vegetable fern leaves extract improved lipid profile level in wistar male rats with dyslipidemianot as good as simvastatin but decreased F2-isoprostane better than simvastatin.

Keywords: Dyslipidemia, Vegetable fern leaves, Lipid profile, F2-isoprostane

How to Cite?: Marlene Irawan, Anak Agung Gde Budhiarta, Ida Sri Iswari, "Comparison between Oral Ethanol Vegetable Fern Leaves (Diplazium esculentum) Extract and Simvastatin to Improve Lipid Profile and Decrease F2-isoprostane Level in Wistar Male Rats (Rattus norvegicus) With Dyslipidemia", Volume 10 Issue 4, April 2021, International Journal of Science and Research (IJSR), Pages: 615-619, https://www.ijsr.net/getabstract.php?paperid=MR21412135858, DOI: https://dx.doi.org/10.21275/MR21412135858

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