Anti-haemorrhoidal Activity of the Decoction of Liana Bark from Landolphia owariensis P. Beauv. (Apocynaceae)

Abstract: This study consists in evaluating the antihemorrhoidal activity of the decocted bark of dried liana of Landolphia owariensis (Apocynaceae). Adjimou Ledjou's methods. J., 2002 and Mohammed Azeemuddin et al., 2014 were used. Acclimatized wista rats have free access to water and food before experimentation. The preventive and curative activity was evaluated. Hemorrhoidal seizures have been induced with anal croton oil. Oral therapeutic doses varied from 5.5; 55; 110; 165 and 550 mg / kg body weight. In the preventive evaluation, the rats are previously treated with the decoct? before induction of the attacks. As a cure, they are treated as soon as the attacks appear. After treatment, the degree of prevention, the times for the resorption of the attacks, histological sections of rectoanal tissue were analyzed. The decoct? has preventive and curative anti-hemorrhoidal activity. The effective dose varies between 5.5 and 550 mg / kg. Above 550 mg / kg, the response is stationary; the resorption time is the same. Resorption varies between 5 and 8 days depending on the dose administered. As a preventive measure, the time taken for the onset of seizures is long, the longer the dose administered is large.

Keywords: Landolphia owariensis, hemorrhoids, anti-hemorrhoidal activity

Edition: Volume 10 Issue 6, June 2021,

Pages: 522 - 530