A Study on Diagnostic Accuracy of Modified Cajals Trichrome Stain in Suspected Cases of Microinvasion

Latha Mary Cherian, Dhanya Sasikumar, Pradeesh Sathyan, Kristina Sabu

Abstract: Microinvasive oral squamous cell carcinoma (OSCC) is an early stage malignancy which exhibits invasion of superficial lamina propria without involving invasion of deeper structures. Even though Hematoxylin and Eosin staining remains the cornerstone of contemporary cancer diagnosis, histopathological diagnosis of initial epithelial pathology may be challenging. Masking of small and obscure invasive components and the basement membrane by the inflammatory reaction poses a hindrance for detection of microinvasion. The present study endeavours to use Modified Cajal’s trichrome stain for cost effective, easy diagnosis of microinvasive squamous cell carcinoma.

Keywords: Microinvasion, Hematoxylin and Eosin, Modified Cajal’s trichrome stain