Not Every Mass is a Monster-Meigs Syndrome, A Chameleon in Gynecologic Oncology: Four Case Reports and an Extensive Literature Review

Dr Ajay Sharma, Dr Anjali Sharma, Dr Paresh Sharma

Abstract: Meigs syndrome, characterized by the triad of a benign ovarian tumor, ascites, and pleural effusion, often mimics advanced ovarian malignancy, leading to potential misdiagnosis and overtreatment. Elevated CA-125 levels, commonly associated with epithelial ovarian cancers, can also be observed in Meigs syndrome, further complicating the diagnostic process. This report presents four cases where initial assessments suggested malignancy due to imaging findings and elevated tumor markers. However, histopathological evaluations confirmed benign ovarian tumors, and postoperative resolution of ascites and pleural effusion affirmed the diagnosis of Meigs syndrome. A comprehensive literature review underscores the importance of considering Meigs syndrome in differential diagnoses to prevent unnecessary aggressive interventions. This study emphasizes that "no blind treatment is also a treatment", advocating for thorough diagnostic evaluations before initiating therapy.

Keywords: Meigs syndrome, Ovarian mass, Benign ovarian tumors, ovarian mass with pleural effusion

How to Cite?: Dr Ajay Sharma, Dr Anjali Sharma, Dr Paresh Sharma, "Not Every Mass is a Monster-Meigs Syndrome, A Chameleon in Gynecologic Oncology: Four Case Reports and an Extensive Literature Review", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1441-1442, https://www.ijsr.net/getabstract.php?paperid=MR25826103326, DOI: https://dx.doi.org/10.21275/MR25826103326