Review Article: Antioxidant Activity of Ziziphus oenoplia Leaves Extract in Rats

Krishnapal Nagda, Dr. Jai Singh Vaghela

Abstract: This review evaluates the antioxidant activity of Z. oenoplia leaves extract by synthesizing findings from phytochemical analyses, in vitro assays, and in vivo studies in rat models. Phytochemical profiling reveals that the leaves are rich in polyphenolic compounds, particularly flavonoids, tannins, and phenols, which are key contributors to free radical scavenging activity. In vitro studies using methanol, aqueous, and ethyl acetate extracts demonstrate strong antioxidant activity across standard assays, including DPPH and hydrogen peroxide scavenging models. Evidence from in vivo research, notably in alloxan-induced diabetic rats, indicates that ethanolic and aqueous extracts exert significant hypoglycemic and hypolipidemic effects, indirectly reducing oxidative stress. Additional findings from studies on other plant parts, such as the roots, further support its protective role against oxidative and tissue injury. Collectively, these results suggest that Z. oenoplia leaves extract possesses both direct antioxidant activity through free radical neutralization and indirect benefits via metabolic regulation. However, the absence of studies in healthy animals using direct oxidative stress markers, such as superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA), highlights a critical gap. Future research should focus on establishing baseline antioxidant effects in normal physiology and elucidating molecular pathways to advance its therapeutic application.

Keywords: Ziziphus oenoplia, antioxidant properties, phytochemical compounds, oxidative stress, metabolic regulation

How to Cite?: Krishnapal Nagda, Dr. Jai Singh Vaghela, "Review Article: Antioxidant Activity of Ziziphus oenoplia Leaves Extract in Rats", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 950-952, https://www.ijsr.net/getabstract.php?paperid=MR25821044213, DOI: https://dx.doi.org/10.21275/MR25821044213