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Masters Thesis | Obstetrics and Gynecology | India | Volume 12 Issue 4, April 2023
A Study on Maternal Serum Glycosylated Fibronectin as a Predictor of Pre-Eclampsia in Antenatal Women between 20-36 Weeks of Gestational Age
Dr. Indira Priyadharshini | Dr. Jothi Sundaram [2]
Abstract: Background and aim: Preeclampsia remains a major problem of modern obstetrics with insufficiently elucidated etiology. Early detection would diminish maternal and fetal mortality and morbidity. Preeclampsia is a multi system disorder and develops typically after 20 weeks of gestation with proteinuria in a previously normotensive and non proteinuric women. Incidence of hypertensive disorders contributes to 9% of maternal mortality in Asia and12% in India. Preeclampsia is associated with increased maternal glycosylated fibronectin and several studies have reported that during the clinical phase of PE the maternal serum maternal fibronectin concentration is increased. Aim: The aim of this study is to determine the maternal serum values of glycosylated fibronectin in antenatal women between 20-36weeks of gestational age. In order to evaluate their relevance in the predictor of preeclampsia. This study is to investigate the prognostic value of abnormal serum glycosylated fibronectin as predictor of preeclampsia. Methods: It is a prospective randomized observational study in Pregnant woman in gestational age between 20-36 weeks of gestational age coming to regular Antenatal OPD in the Department of Obstetrics and gynecology, government Rajaji Hospital attached to Madurai Medical College, Madurai for the period is 8months. The study is conducted on 150 cases. The study subjects will be followed up till delivery for each visit pt advised to check BP, urine albumin and watch for development of preeclampsia. Results: In our study, most of the patients were between the age group of 20 to 35years. There is development of preeclampsia in a women with increased levels of maternal serum glycosylated fibronectin. Conclusion: In our study there is significant independent contribution from maternal serum glycosylated fibronectin which was found to be increased in screening of PE women compared to normotensive pregnant women. Early prediction of Preeclampsia could potentially improve the outcome by close surveillance of the patient and would be the basis of the prophylactic medications, starting from the first trimester to improve placental invasion,, uteroplacental circulation and so decreasing the prevalence of the disease.
Keywords: preeclampsia, maternal glycosylated fibronectin, predictor, ultrasonography
Edition: Volume 12 Issue 4, April 2023,
Pages: 749 - 753