Can C - reactive protein As a Marker for Fasting Hyperinsulinemia in Subclinical Hypothyroidism

Anjaneya Prasad V, Pradeep Babu KV

Abstract: Objective: Subclinical hypothyroidism is a sub clinical entity with elevation of TSH and without elevation of T3 and T4. The purpose of this case – control study was to corelate C-reactive protein to Subclinical hypothyroidism with and without Fasting hyperinsulinemia. Method: This study was done at the Department of Medicine DR. PSIMS & RF, Chinaoutpally, A. P. India between Jan 2012 to Dec 2012.100 patients (50 cases, 50 controls) above 18 years of age were included in the study. The TSH reference range was 0.4-4.5 IU/ml and serum free thyroxine level between 5.13 – 14.06 g/dl. Results: C-reactive protein levels were found to be significantly higher in Subclinical hypothyroidism patients with Fasting hyperinsulinemia than Subclinical hypothyroidism alone. Conclusions: Patients with Subclinical hypothyroidism with high fasting insulin levels have higher serum CRP, total and LDLcholesterol levels than controls.

Keywords: Subclinical hypothyroidism, C-reactive protein, Insulin