Hyperuricemia: Increase Risk of Maternal & Fetal Complications (Outcome) in Preeclampsia

Dr Monali Rewatkar, Dr Kshama Kedar, Dr Arun Tadas

Abstract: Background - Preeclampsia is a multisystem disorder & most common cause of maternal & fetal death in India & all over the world [1]. Hypertension in pregnancy after 28 wks can cause poor perinatal outcome. Increased serum uric acid level (hyperuricemia) in Preeclampsia [2] further increases risk of complicated pregnancy like premature delivery, foetal distress, maternal & fetal death etc So, increase serum uric acid level is one of the prognostic factor for determination of perinatal outcome. Materials & Methods - 100 Preeclampsia women admitted in OBGY ward after 28 wks of pregnancy were selected as cases & 100 Normotensive pregnant women attending Biochemistry OPD were selected as control (>28 wks of pregnancy. Serum Uric acid level was estimated in Biochemistry clinical Laboratory on Autoanalyser in all cases and control & values was compared. Follow up study was taken of Preeclampsia women with hyperuricemia regarding their maternal & fetal outcome till delievery & its outcome was correlated with hyperuricemia. Result – Our study shows increase level of serum uric acid in Preeclampsia compared to Normotensive which is statistically significant ( P value < 0.05) which shows association of hyperuricemia with Preeclampsia. Current study also shows that there is positive and statistically significant relationship between hyperuricaemia in Preclampsia patients with maternal & fetal outcome. Preeclampsia with hyperuricemia shows increase risk of maternal & fetal complications like PPH, premature deliveries, IUGR, foetal distress etc, resp, which is statistically significant. Conclusion - Preeclampsia is a common cause of maternal death. Hyperuricemia progresses disease, Increase serum uric acid level in Preeclampsia increases risk of maternal & fetal complications & poor perinatal outcome. So early screening for Serum uric acid level must be advised in pregnancy to prevent further risk. Key words: Hyperuricaemia, Preeclampsia, Fetal outcome, Maternal outcome

Keywords: Hyperuricaemia, Preeclampsia, Fetal outcome, Maternal outcome

How to Cite?: Dr Monali Rewatkar, Dr Kshama Kedar, Dr Arun Tadas, "Hyperuricemia: Increase Risk of Maternal & Fetal Complications (Outcome) in Preeclampsia", Volume 8 Issue 9, September 2019, International Journal of Science and Research (IJSR), Pages: 857-860, https://www.ijsr.net/getabstract.php?paperid=ART20201217, DOI: https://dx.doi.org/10.21275/ART20201217